Late-onset spondylitis mainly refers to patients with ankylosing spondylitis that develops after the age of 45. Treatment methods mainly include conservative treatment and surgical treatment. 1. Conservative treatment: It mainly includes heat therapy, massage, physical therapy, rehabilitation training, drug treatment and so on. Drug therapy includes non-steroidal anti-inflammatory drugs, anti-rheumatic drugs, such as diclofenac sodium, salicylazosulfapyridine, biologics and so on. Early and aggressive conservative treatment can control the progression of inflammation, slow down the change of spinal curvature, prevent muscle atrophy and improve the healing process. The above medications should be used under the guidance of a doctor, and avoid self-medication. 2. Surgery: For patients whose disease progresses rapidly and conservative treatment is ineffective, or patients with severe deformity leading to functional impairment, surgical intervention can be considered to improve their symptoms and quality of life. Surgical methods mainly include total hip replacement, spinal orthopedic surgery and so on. The specific type of surgery needs to be decided by a professional doctor after a comprehensive assessment based on the patient’s own condition. If late-onset spondylitis is diagnosed, early and standardized treatment is recommended to minimize the adverse effects of the disease.