Pregnancy and childbirth were once listed as contraindications for SLE, but today, through extensive clinical observations, most SLE patients can safely become pregnant and have children after their disease is controlled. Generally speaking, pregnancy should be allowed when there is no significant organ damage, the disease has been stable for one year or more, immunosuppressive drugs (cyclophosphamide, methotrexate, etc.) have been stopped for six months, and hormones are only maintained in small doses. The risk of miscarriage, preterm delivery, stillbirth and induced deterioration of maternal disease is present in non-remission SLE pregnancy and childbirth. Therefore, pregnancy should not occur when the disease is unstable. If the disease is active during pregnancy, the decision to terminate the pregnancy should be made on a case-by-case basis. If the disease is significantly active in the first trimester, termination of pregnancy is recommended. Post-pregnancy medication requires consultation between the obstetrician and rheumatologist. Immunosuppression during pregnancy can affect fetal growth and development leading to malformations. I. What are the chances of developing SLE in a loved one? Several large foreign studies have found that first-degree relatives with SLE, i.e., brothers, sisters, parents, and children, are slightly more likely to develop SLE than the general population. Among them, about 10 percent of daughters and 2 percent of sons have SLE. When one fraternal twin has SLE, the other twin has a 5-10% chance of having SLE, and when one identical twin has SLE, the other twin has a two-thirds chance of having the disease. Patients with SLE often ask if all their family members need to have their blood tested. The answer is no. About half of the lupus patients have antinuclear antibodies in their first-degree blood, but they do not necessarily develop the disease. Is the immune function of SLE patients enhanced or depressed? In patients with SLE, the body loses normal immune tolerance under the action of unknown reasons, resulting in immune cells not being able to correctly identify their own tissues and autoimmune reactions, i.e. immune disorders. Specifically, in the peripheral blood of patients with SLE, B cells are highly activated and produce a large number of autoantibodies. These antibodies only combine with their own tissue antigens to form immune complexes, which circulate around the body with the blood and cause systemic vasculitis, followed by lupus nephritis, pneumonia, encephalitis, myocarditis, etc., resulting in multi-system and multi-organ damage. If the immune system of human body is compared to an army, immune disorder is like the army of the country having infighting and killing each other without distinguishing the enemy. 3. Is SLE contagious? When many patients hear the name of this disease or see lupus patients around them, they will inevitably ask: Is this disease contagious? The answer is no, SLE is not contagious from one person to another. The occurrence of SLE is mainly related to immune factors, genetic factors and environmental factors. The underlying cause is immune dysfunction. It is not a disease caused by various pathogens (bacteria, viruses, fungi, etc.) and is not likely to be transmitted from person to person. Therefore when in contact with the patient, there is no need to have the concern of being infected. During the stable period, SLE patients can work and study like normal people and participate in normal social activities. Can SLE patients get married? Some young women with SLE have a heavy burden on their minds and lose confidence in life and future after they get SLE, so they give up on themselves and cannot get married for fear that others will think of them. In fact, this approach is not desirable. First of all, the disease itself is not incurable, as long as you can adhere to the treatment, the disease can be completely controlled, and even the obvious parts of the rash can be gradually eliminated. In addition, if there is a beautiful family, love and support from the loved ones, the patient will be able to build up confidence and determination to overcome the disease, which is conducive to the recovery of the disease.