In general, psychiatric symptoms may occur when the central nervous system is involved. The development of psychiatric symptoms in SLE is one of the critical clinical conditions. When psychiatric symptoms occur in patients with lupus, the first thing to consider is lupus encephalopathy due to disease activity, which requires hormonal shock therapy. Secondly, in patients who have been diagnosed and treated for a long time, co-infection is not uncommon, and the common ones are tuberculosis, fungus, bacteria and virus, etc. In this case, the application of hormone has a counter indication, and sometimes repeated lumbar puncture is needed to assist in diagnosis and decide the next treatment plan. It is important to note that a few patients, especially those with a history of trauma or psychiatric illness and family history, may develop or have psychotic episodes at the same time, in which case, a psychiatrist is required to assist in the diagnosis and treatment.