SLE is an autoimmune-mediated diffuse connective tissue disease with immune inflammation as the prominent manifestation. The presence of multiple autoantibodies represented by antinuclear antibodies in the serum and multisystem involvement are the two main clinical features of SLE. The clinical manifestations of SLE are as follows: 1. General symptoms: The ratio of men to women involved in the disease is 1:7 to 9, and the age of onset is 20 to 40 years old most often, while young children or the elderly can also develop the disease. Fatigue and weakness, fever and weight loss. 2. Skin and mucous membranes: The manifestations are diverse and can be broadly divided into two categories: specific and non-specific. ①Specific skin lesions include pteroid erythema, subacute cutaneous lupus erythematosus, discoid erythema and neonatal lupus. Non-specific lesions include photosensitivity, alopecia, oral ulcers, cutaneous vasculitis, Raynaud’s phenomenon, urticaria-like rash and, rarely, lupus lipofuscinosis or deep lupus and lupus erythematosus. 3. Skeletal muscles: manifestations include arthralgia, arthritis, joint deformity (10% of X-rays have damage) and myalgia and muscle weakness. 4. Heart involvement: there may be pericarditis (4% of patients have signs of pericardial compression), myocarditis mainly manifesting as congestive heart failure and heart valve lesions (endocarditis). Coronary arteritis is rare and mainly manifests as chest pain, abnormal ECG and elevated cardiac enzymes. 5, respiratory system involvement: pleurisy, pleural effusion (20%-30%), crumpled lung syndrome mainly manifested as breath-holding sensation and diaphragm dysfunction); interstitial lung lesions seen in 10%-20% of patients, of which 1%-4% manifested as acute lupus pneumonia, pulmonary embolism (5%-10%, usually positive for anti-cardiolipin antibodies), pulmonary hemorrhage and pulmonary arterial hypertension (1%) can occur. 6, kidney: clinical manifestations of nephritis or nephrotic syndrome. In nephritis, red blood cells, white blood cells, tubular and proteinuria appear in the urine. Renal function measurements are normal in the early stages, progress gradually, and uremia may develop in the later stages. Nephrotic syndrome and laboratory manifestations include generalized edema with varying degrees of abdominal, thoracic and pericardial effusions, massive proteinuria, decreased serum albumin, inverted albumin ratio and hyperlipidemia. 7. Neurological involvement: There may be convulsions, psychiatric abnormalities, organic brain syndrome including organic amnesia/cognitive dysfunction, dementia and altered consciousness, others may include aseptic meningitis, cerebrovascular accident, transverse myelitis and lupus-like sclerosis, and peripheral neuropathy. 8. Hematologic involvement: anemia, reduced white blood cell count, thrombocytopenia, enlarged lymph nodes and splenomegaly may be present. 9. Digestive system involvement: poor appetite, nausea, vomiting, diarrhea, ascites, hepatomegaly, abnormal liver function and pancreatitis. Less common are mesenteric vasculitis, Budd-Chiari syndrome and protein-losing enteropathy. 10.Other: It can be combined with hyper- or hypothyroidism, dry syndrome and other diseases.