Combined oxidative phosphorylation deficiency is a disorder caused by a defect in the mitochondrial oxidative phosphorylation system, which is an inherited disease. Oxidative phosphorylation is the process by which energy released from the oxidation of a substance in the mitochondria is transferred through the respiratory chain to ADP and inorganic phosphate to produce the high-energy compound APT. Combined oxidative phosphorylation deficiency is a condition in which this energy metabolism is abnormal and fails to carry out its normal metabolic functions, resulting in symptoms caused by abnormalities in other systems. There are currently 39 known types of APT, each with a different causative gene. Because the disease is a rare autosomal recessive disorder with a lack of specificity in its clinical manifestations, death often occurs before a definitive diagnosis is made, and there are currently only 29 reported cases worldwide. If infants and young children have microcephaly, feeding difficulties, developmental delays, developmental abnormalities and other manifestations, it is recommended that they go to the pediatrician in a timely manner to identify the cause of the disease and timely treatment, and not to be careless, so as not to affect their lives.