Viral rise after entecavir discontinuation is a common discontinuation reaction, and re-taking entecavir or alternative treatment with other drugs may be considered. Entecavir is indicated for the treatment of chronic adult hepatitis B with active viral replication, persistent elevation of aminotransferase ALT or active lesions in liver tissue. Its main adverse reactions include headache, dizziness and nausea. It is contraindicated in people who are allergic to the product. This product is sometimes associated with worsening of liver conditions when the drug is discontinued. If you have not been on the drug for a long time, you can consider continuing treatment with entecavir, and you can have your Hepatitis B Penta and Quantitative DNA retested about once every six months. If you have been taking entecavir for quite a long time and there is no significant reduction in viral replication, you can consider switching to other drugs, such as interferon. If the virus rises after entecavir is discontinued, you should follow up with your doctor, improve your examination, and follow your doctor’s instructions for effective treatment. The above medication should be used in accordance with the doctor’s instructions, and should not be used arbitrarily by oneself.