The difference between glutamine and methylcobalamin is mainly reflected in the drug indications, pharmacological mechanisms and adverse drug reactions. 1. Indications: Glutamine is mainly used in the treatment of premenstrual tension syndrome, menopausal syndrome and neurosis; while methylcobalamin is mainly used in the treatment of peripheral neuropathy. 2. Pharmacological mechanism: Glutamine has the effect of regulating endocrine balance disorders and autonomic dysfunction; while methylcobalamin is a kind of endogenous coenzyme B12, which can inhibit neurodegeneration by promoting the utilization of folic acid, nucleic acid metabolism and synthesis, and protein synthesis. 3. Adverse reactions: glutamine common adverse drug reactions for excessive oil secretion, breast swelling, nausea, stomach upset, etc.; methylcobalamin common adverse drug reactions include nausea, vomiting, loss of appetite. Glutathione and methylcobalamin need to be used under the guidance of a physician, it is recommended that patients who need to take these two drugs to the relevant departments of the regular hospital for consultation.