Many patients ask after surgery if they need estrogen supplementation without their ovaries. Or some patients ask if they can use hormone replacement therapy after they develop severe menopausal symptoms (such as hot flashes, night sweats, distractibility, etc.). This question has also been explored by the medical community. Post-operative estrogen supplementation may wake up “sleeping” cancer cells. Although the surgery has removed the uterus, ovaries and all visible lesions, there may still be tumor cells that are invisible to the naked eye that are sleeping. As we mentioned earlier, endometrial cancer is an estrogen-dependent tumor, and if estrogen is used, it may awaken these “sleeping” cancer cells and cause them to germinate in the pelvic or abdominal organs. Therefore, we currently do not recommend routine estrogen supplementation for postoperative patients. If a patient has severe menopausal symptoms and needs hormone replacement therapy, we will communicate with the patient about the risks of hormone replacement therapy, and under the monitoring of the doctor, hormone replacement therapy can be carefully administered. There is also another rare case where the patient is very young and it is determined intraoperatively that there is no metastasis and the cancer is mild, so that preservation of the ovaries can be considered for the patient’s quality of life. However, this also carries certain risks and requires preoperative information to the patient about the pros and cons.