Prolactin microadenomas do not usually progress to invasive adenomas, but they should be given high priority. Prolactin microadenomas usually refer to hypothalamic pituitary disorders caused by excessive secretion of prolactin by pituitary prolactin cell tumors. Typical symptoms in these patients are amenorrhea, infertility, breast milk overflow, hyperprolactinemia, and pituitary space-occupying lesions. In patients with clinically symptomatic prolactin microadenomas, they usually do not grow into macroadenomas and do not progress to invasive adenomas. It should be noted that there are some adenomas that are aggressive and present with enlarged adenomas and elevated blood PRL. Once a patient is found to have a prolactin microadenoma, he or she can work with the doctor to improve the patient’s symptoms by choosing medications such as Pergolide and Quinagolide, and improve the patient’s prognosis by choosing surgical treatments and radiation treatments if necessary.