Adapalene speeds up the metabolism of cells in the stratum corneum of the skin, dissolving acne and thus reducing it, and has anti-inflammatory properties that improve inflammatory lesions and make acne subside. Adapalene is generally not recommended for daytime use and can be applied evenly to the affected area at night after cleansing the skin and can usually be left on the skin overnight. Adapalene is sensitive to sunlight and should be avoided from sunlight and ultraviolet rays after use, otherwise it is prone to irritate the stratum corneum due to sunlight exposure, resulting in dryness and peeling. Therefore, it is recommended to use Adapalene at night, which can be applied to the affected area before going to bed and washed off with water the next morning. In addition to the need to pay attention to the time of use, in the process of using Adapalene also need to pay attention to the following matters: 1, the establishment of tolerance: the dosage should be from less to more, so that the skin gradually build up tolerance. If mild skin discomfort occurs, you can shorten the duration of the medication, such as washing off after 1 hour of application, or you can reduce the number of times you use the medication, such as using it again at an interval of 1 day; 2, avoid the use of drugs superimposed on one another: you need to avoid the use of ointment with retinoic acid, both belong to retinoic acid, and the simultaneous use of which is prone to cause strong irritation of the skin, tingling, erythema and desquamation, and so on. If severe erythema, peeling or other allergic reactions occur, the drug should be discontinued; 3, other: during the use of adapalene, try not to stay up all night, do not eat spicy, stimulating food, eat less sweets, less heavy makeup.