According to the instructions of Angong Niuhuang Pills, there is no uniform regulation on whether Angong Niuhuang Pills should be taken in the morning or at night. Patients are advised to take the medicine according to their health condition and follow the doctor’s instructions. Angong Niuhuang Pills, composed of ox horn, buffalo horn concentrated powder, musk, pearl and so on. It has the efficacy of clearing away heat and detoxification (clearing away heat, poison and evil qi from the body), and suppressing fright and opening up the mind. It is used for fever, evil entering the pericardium, high fever convulsion (convulsions due to high fever), delirium tremens (confusion, nonsense); stroke coma and encephalitis, meningitis, toxic encephalopathy, cerebral hemorrhage, septicemia seen in the above symptoms. It should be noted that this drug for the heat closure of delirium, cold closure of delirium shall not be used; this drug contains musk in the prescription, the aroma of running away, damaging fetal qi, pregnant women should be used with caution; during the period of taking the drug should be a light diet, avoid spicy and oily products, so as not to help the fire and phlegm; this drug contains cinnabar, andrographis, should not be overdosed for a long time, liver and kidney insufficiency, be careful with the use of. Angong Niuhuang Pills should not be used indiscriminately, need to be guided by a professional Chinese medicine practitioner.