High squamous epithelial cancer antigen suggests a benign or malignant disease such as squamous lung cancer or psoriasis, which needs to be treated; there is also a smaller possibility that it is a false positive and actually fine. Squamous Epithelial Carcinoma Antigen (SECA) is a glycoprotein that is widely found in squamous epithelial cells of the skin, esophagus, cervix and lungs. False positives may occur if some of the skin cells are scraped in by poor blood collection techniques or if the blood specimen is contaminated by body fluids such as sweat and saliva. Nowadays, the examination process is strictly in accordance with the standard, and the possibility of false positives is small, but high squamous epithelial cancer antigen still needs to be considered as a result of benign or malignant diseases. Elevated squamous epithelial cancer antigen is commonly found in patients with squamous cell carcinoma of the lung, cervical cancer and esophageal cancer. Benign diseases such as pemphigus, psoriasis, and atopic dermatitis can also lead to elevated squamous epithelial cancer antigen concentrations. It is suggested that patients should combine other tumor markers and other test results to make a comprehensive judgment, and if the above benign or malignant diseases are suspected, they should undergo further examination in time to find out the cause of the disease.