High direct and indirect bilirubin may be due to hepatocellular jaundice, which is caused by a variety of liver diseases and often requires targeted medication such as entecavir, ursodeoxycholic acid, or surgical treatment. If it is caused by viral hepatitis, antiviral medications such as entecavir and tenofovir are often needed, along with anti-inflammatory and choleretic medications such as anti-inflammatory bile tablets and ursodeoxycholic acid, which can help to promote lower bilirubin levels. It may also be caused by other liver diseases, such as cirrhosis and liver failure, and if the condition is more serious, liver transplantation is often required. High levels of both direct and indirect bilirubin often require further examination by a doctor for a definitive diagnosis and early treatment.