A small piece of the toenail suddenly empty, can be related to nail trauma or nail fungal disease and other diseases, the treatment according to the cause of the disease to take surgical treatment, topical drugs, and systemic medication and so on. Nail trauma, empty nails appear, can protect the nails, to avoid infection, to wait for the newborn nails to grow. In severe cases, patients may also choose to have their nails extracted to clean up the blood under the nail and wait for the nail plate to grow back. Empty nails caused by nail fungus disease can be treated with topical medication, first remove the diseased nail with a knife, then use glacial acetic acid solution or tincture of iodine on the local area, and change the medication every day until the new nail grows out; also can be used to soften and peel off the diseased nail by sealing with urea cream, and use topical antifungal medication, such as amorphophallus nail applicator, to treat the disease. Systemic application of drugs can be intermittent shock therapy with itraconazole or continuous administration of terbinafine. For nails with empty nail manifestations, it is recommended to consult a doctor in time to clarify the cause of the disease, and then follow the doctor’s instructions to standardize the cause of the symptomatic treatment.