MaiZhiLing can reduce inflammation and relieve pain, XiaoJinDan has the efficacy of dispersing knots and eliminating swelling, resolving blood stasis and relieving pain, both drugs have a certain effect on epididymitis. However, the efficacy of the two are different, the therapeutic effect is different, can not be directly compared, there is no so-called “which one is better”. Epididymitis is a non-specific infection of the male reproductive system, can be divided into acute and chronic epididymitis, the main clinical manifestations of scrotal swelling discomfort, local pain, can affect the action, and accompanied by general discomfort or high fever. The main ingredient of Mai Zhi Ling Tablet is horse chestnut seed extract, which has the effect of anti-inflammatory and pain relief. Xiao Jin Dan is composed of Cao Wu and Di Long, which has the effect of dispersing knots and eliminating swelling, resolving blood stasis and relieving pain. These two drugs are effective in relieving pain and swelling caused by chronic epididymitis. Note that Mai Zhi Ling may have mild gastrointestinal reactions after taking it, and should be used with caution in patients with gastric ulcers. Xiao Jin Dan is contraindicated in pregnant women and should not be taken with ginseng. Patients with epididymitis should follow the doctor’s instructions for standardized treatment, for patients with chronic epididymitis can also be under the guidance of a professional Chinese medicine practitioner to identify and treat the disease by looking at, choosing the appropriate and effective Chinese medicine treatment. Patients should not blindly self-medication, in order to avoid ineffective treatment and delay the condition.