Right thigh pain in microscopic lesion nephropathy should be alerted to venous thrombosis of the lower extremities, but also consider that it may be caused by physiologic reasons, osteomyelitis, and other reasons. General treatment, drug treatment and interventional therapy can be chosen according to the causes. 1. Physiological reasons: prolonged standing, excessive exercise and other calf muscle strain can lead to pain in the right thigh of patients with microscopic lesion nephropathy, which can be relieved by rest, hot compresses, physiotherapy and other measures. 2. Lower extremity venous thrombosis: patients with microscopic lesion nephropathy are prone to thrombosis due to increased blood viscosity and imbalance of coagulation and anticoagulation system caused by blood concentration and hyperlipidemia. Lower extremity venous thrombosis can cause blood reflux obstruction in thigh area and blood stasis leading to pain. Thrombolytic treatment can be carried out by applying streptokinase as prescribed by doctor, or interventional treatment can be carried out to take out the thrombus. 3. Osteomyelitis: patients with microscopic lesion nephropathy lose a lot of albumin from urine, resulting in hypoalbuminemia, and immunoglobulin in the body is lowered, resulting in decreased resistance of the patients, and pathogens from other parts of the body such as respiratory tract infections can be spread to the femur through the blood circulation to develop osteomyelitis, and the stimulation of inflammation leads to pain in the right thigh. You can take antibiotics such as cefuroxime and vancomycin as prescribed by your doctor. When the right thigh pain persists in microscopic lesion nephropathy, you should go to the hospital in time to improve the examination and give targeted treatment after clarifying the cause of the disease.