DPP-4 inhibitors are new types of hypoglycemic drugs, what are they? What is the mechanism of action? What are the advantages and disadvantages? This is what diabetic patients should know. Mechanism of action of DPP-4 inhibitors – a new type of glucose-lowering drug based on the enterostatin mechanism. – Mechanism of action Increases glucagon-like peptide-1 (glp-1), GIP and insulin levels and decreases glucagon levels by blocking the action of the DPP-4 enzyme. common drugs in the DPP-4 inhibitor class – Selegiline – Saxagliptin – Advantages of the DPP-4 inhibitor class – Significant efficacy – No effect on body weight – No significant gastrointestinal side effects – Low incidence of hypoglycemia – No increase in the incidence of cardiovascular events – Highly safe and tolerable – Safe for elderly patients Disadvantages of DPP-4 inhibitors – Adverse effects such as headache, nasopharyngitis, cough, constipation, dizziness and increased sweating, but the incidence is very low – More expensive, not yet included in the list of DPP-4 inhibitors in China