Young and middle-aged women in many people’s faces more or less will have a variety of spots, medical research now shows that: all kinds of spots on the skin is mainly by the melanin cells in the skin secretion of melanin metabolism abnormalities caused by melanin production is extremely complex physiological and biochemical processes, which are controlled by a variety of enzymes and factors of regulation and counter-regulation, the mechanism is far from being fully understood. There are also hormones in the body and the nervous system involved in the role. In vitro various physical (such as sun exposure) chemical (cosmetics, etc.) factors also have a certain impact. Many patients can not be eliminated by multiple treatment, dermatologists are helpless; turn to cosmetics, shopping malls, the bottom of the cosmetic counters in a variety of spot removal, eliminate spots, spotting products, a wide range of people can not choose. Because some compounds of mercury have whitening effect. Some unscrupulous businessmen will be used in spot-removing and whitening cosmetics and lead to mercury poisoning. Mercury is a kind of toxic heavy metal, can damage pigment cells, reduce melanin production, to achieve the so-called rapid spot whitening, but mercury in the spot whitening at the same time, but also on the human body will be harmful. Mercury will be absorbed through the skin into the human body, damage to the human nervous system, kidneys, hematopoietic system, liver and reproductive system, resulting in infertility. In pregnant women, it can also affect the development of the fetus through the placenta. Breastfeeding drugs must master the indications, as far as possible, choose the drugs that have been clearly safer for breastfeeding; the time of use can be selected at the end of breastfeeding, the best interval from the next breastfeeding for more than 4h; for the necessity of the use of drugs that do not have a clear impact on the baby, it is best to suspend breastfeeding; the application of larger doses of drugs or a longer period of time, it is best to monitor the breast’s blood concentration, and to adjust the interval between the use of medication and breastfeeding. Topical drugs should also be used with caution during breastfeeding, because some topical drugs can be absorbed through the skin into the bloodstream, damaging the health of the fetus or the breast. When women are pregnant, due to the changes of hormone and endocrine, it will also make the pigmentation of spots deepen or grow out. The choice of spot removal products must also look at the packaging to see whether to indicate the special use of cosmetic health approval number, where in the trade name of the word “spot removal”, or in the instruction manual shows that there is a spot removal function, but not labeled with the number of the spot removal cosmetics, at least can be considered as substandard production.