Common side effects of immunoglobulin are mild, such as transient headache and nausea, but serious side effects such as thrombosis and hemolysis can occur. Intravenous immunoglobulin (IVIG) can be used in primary immunodeficiencies, infectious diseases, and immune-related diseases, and plays an important role in defense against infections and in immune regulation, but it is contraindicated in people who are allergic to human immunoglobulin or who have a history of other severe allergies, and in people who are selectively IgA-deficient and have anti-IgA antibodies. Individuals may experience transient headache, nausea, panic and other adverse reactions during IVIG infusion, which may be related to individual differences or the infusion rate, and generally can recover spontaneously without special treatment. However, there are reports in the literature of serious thrombosis caused by IVIG infusion, clinically severe headache, chest pain, myocardial infarction, congestive heart failure, deep vein thrombosis and stroke, in addition, hemolysis phenomenon after IVIG treatment can be seen in individual cases, in order to prevent the occurrence of this phenomenon, the recipient’s erythrocytes should be used to carry out a test of cross-matching with lVIG before use. Note that the immunoglobulin for intravenous injection is exclusively for intravenous injection, and the drug should not be used if there is turbidity, precipitation, foreign matter, etc. It should be used up once after opening and should not be used twice. The use of immunoglobulin is recommended to follow the doctor’s advice, avoid self-medication.