Left ventricular wall motion abnormalities are seen in dilated cardiomyopathy and myocardial infarction, which can be treated to alleviate the symptoms of the disease, and the ventricular wall motion abnormalities that have already developed are difficult to reverse. 1. Dilated cardiomyopathy: most of the cardiomyopathy is caused by heredity, and the ventricular wall motion is diffusely reduced. The main focus is to treat heart failure and prevent complications. (1) Improve the prognosis of heart failure by applying angiotensinase inhibitors (valsartan, chlorosartan, etc.), β-blockers (bisoprolol, metoprolol, etc.), aldosterone receptor antagonists (spironolactone) and other drugs. (2) To relieve the symptoms of heart failure, cardiac stimulants (digitalis, etc.), diuretics (furosemide, hydrochlorothiazide, etc.), and vasodilators (isosorbide nitrate, etc.) should be used. The latest guidelines advocate a new quadruple anti-heart failure therapy, i.e., angiotensinase inhibitors/angiotensin receptor inhibitors/angiotensinase enkephalinase inhibitors, β-blockers, aldosterone antagonists combined with sodium-glucose co-transporter protein 2 inhibitors (dalgoglobulin, engeleukin, etc.). (3) Thromboembolism is a common complication, requiring long-term oral anticoagulants such as warfarin, dabigatran, and rivaroxaban. 2. Myocardial infarction: when the infarction area is large, it will lead to limited and staged weakening of ventricular wall motion. The treatment of myocardial infarction mainly includes coronary expansion, antiplatelet, lipid regulation and other medications, commonly used drugs include isosorbide nitrate, aspirin, clopidogrel, tegretol, atorvastatin, resuvastatin and so on, and thrombolysis or stenting or even coronary bypass grafting is needed if necessary. Abnormal ventricular wall motion should be found in the hospital, please ask the doctor to guide the treatment, the use of drugs should also be under the guidance of the doctor.