The decline of ovarian function in normal women starts at the age of 45-50 years, which is a physiological phenomenon; if ovarian failure is caused by follicular depletion, atresia or medical factors in the ovaries before the age of 40 years, it is a pathological phenomenon called premature ovarian failure. The cause of premature ovarian failure is unclear and there is no effective means of prevention. For physiological ovarian failure, if the perimenopausal symptoms are serious and affect one’s life and work, hormone replacement therapy can be applied. In addition to relieving symptoms, hormone replacement can also prevent cardiovascular disease or osteoporosis, etc. However, it is important to exclude contraindications to hormone replacement in gynecological examination first, and then give targeted and individualized treatment according to your situation, and also take regular follow up or phytomedication. For patients with premature ovarian failure, those who have fertility requirements but cannot conceive naturally can be treated in the reproductive medicine department, while those without fertility requirements should be treated mainly to relieve symptoms and reduce long-term complications. The most common treatment for the symptoms of declining ovarian function is hormone replacement therapy, and maintaining a good mood and exercising is also essential for physical conditioning.