Patient male,42 years old v Enhanced CT in January 2015 showed multiple metastases in both lungs and mediastinum, with large intrapulmonary nodes of 2.5 cm and large mediastinal lymph nodes of 3.5 cm. v Expanded resection of left heel malignant melanoma with skin grafting in February 2015 at Medical Academy Cancer Hospital v Pathological genetic testing showed Kras, Braf, c-kit wild type. Ø Brain MRI plain scan did not show any abnormality, suggest enhancement if necessary Ø Whole body bone imaging 1, left foot bone, knee joint, upper tibia metabolism is slightly higher than the contralateral side, consider related to limb movement restriction, suggest follow up. Ø Pelvic CT (-) Ø Superficial lymph node ultrasound Multiple lymph nodes in the left N fossa 1.0*0.8cm in size v Poor physical status before admission, chest tightness and panic after activity, occasional nausea, weight and strength loss, thalidomide 200mg qd orally given as an outpatient, nausea improved and physical status improved v Case discussion in the department after admission v 2015-03-27 and 2015-05-1 Temozolomide 300mg d1-d5 + thalidomide 200mg qd q28 oral chemotherapy was administered for 2 cycles, respectively, with smooth course and no significant adverse effects. Chinese medicine comprehensive treatment § 1) static dose of Kangai injection to benefit the qi and strengthen the immunity; § 2) Chinese medicine to strengthen the spleen and kidney, resolve the phlegm and disperse the knots, the self-prepared formula is as follows: § Yam 10 Fried Atractylodes 15 Radix Codonopsis 15 Radix Codonopsis 15 Roasted Astragalus 30 § Leucospermum 15 Chen Pi 6 Semen 30 Serpentine 30 § Lungwort 15 Dan Pi 10 Ghost arrow feather 15 Poria 10 § Tu Yuan 10 Stone see through 10 Jiao San Xian 30 Jiang Han Xia 10 § 3) Foot bath II formula for foot soaking. Before treatment Wang Jianbin, Department of Oncology, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine After treatment