The following factors can cause amylase to rise: 1. Gastroenteritis: Gastroenteritis can cause some damage to the pancreas, and gastroenteritis can also cause impairment of the intestinal mucosal barrier, both of which may cause amylase to rise. 2. Pancreatic diseases: For example, acute pancreatitis, amylase starts to rise within twelve hours after the onset of the disease. The increase is large and lasts for three to five days. 3. Intestinal diseases: Diseases such as duodenal ulcer, intestinal obstruction and mesenteric infarction can cause amylase to rise, but the increase is not as large as in pancreatic diseases. 4. Macroamylasemia: This causes the kidneys to fail to remove amylase and immunoglobulins in the blood, and the polymer produced by the combination causes amylase to rise. 5. Malignant tumors: For example, lung cancer, ovarian cancer, etc., the ectopic synthesis of tumor tissue may lead to amylase elevation, and amylase will generally drop significantly after treatment.