In the advanced stage of liver cancer, patients die quickly and suffer exceptionally. Generally, the signs before death of liver cancer can be clarified from medical history, clinical symptoms, physical signs and imaging diagnosis. In the advanced stage of liver cancer, patients have obvious consumption, malignancy, inability to eat, obvious wasting, generalized swelling, jaundice, liver disease face as well as having gastrointestinal symptoms, such as nausea, vomiting and gastrointestinal bleeding. On general examination there is severe jaundice, petechiae and petechiae on the skin all over the body, swelling, and a distended abdomen with pressure pain and positive ascites signs. Routine imaging suggests a hepatobiliary tumor with systemic multiple metastases, liver failure, massive ascites, and marked enlargement of the liver and spleen. After clinical as well as imaging examinations suggesting these conditions, patients should beware that they have a prognosis of death.