The reason why HPV vaccine cannot be given at the age of 45 is because the HPV vaccine available on the market now is for women aged 9-45, the bivalent vaccine is for women aged 9-45, the quadrivalent vaccine is for women aged 25-45, and the nine-valent vaccine is for women aged 16-26. The older the relative age, the less effective the defense mechanism is, so the HPV vaccine is generally not advocated at age 45, but that does not mean it is absolutely not available. In addition, the high incidence of sexual life is in women aged 18-28, a period of sexual activity and a higher chance of HPV infection; over 45 years of age, women’s ovarian function declines and the chance of HPV infection decreases, so it is generally stipulated that the HPV vaccine will no longer be given to women aged 45, but if you especially want to be vaccinated with HPV, you can also be prescribed by a doctor for Preventive vaccination.