Alcohol is not recommended for patients while taking Mirtazapine because the drug Mirtazapine is metabolized through the liver and requires liver enzymes to assist in the metabolism of the drug. In case of heavy drinking, alcohol is also metabolized mainly through the liver and can affect the effect of liver enzymes. Drinking alcohol while taking Mirtazapine, the two may have some reaction, which will affect the metabolism or absorption of Mirtazapine in the body, and thus affect the effectiveness of Mirtazapine. Some patients who are more sensitive may experience excessive sedation, dizziness, weakness, etc. Some people may also experience panic, chest tightness and other discomforts. Therefore, it is not recommended to drink alcohol when taking psychotropic drugs such as Mirtazapine, or to drink tea, coffee, and smoke cigarettes.