The anal sensation may be caused by perianal abscess, acute gastroenteritis, pelvic inflammatory disease, colorectal tumors, etc. Specific treatment drugs should depend on the situation. 1. Perianal abscess: there is often perianal redness, swelling and hot pain, patients may have fever, anal swelling, oral antibiotics such as levofloxacin, cefixime, metronidazole, etc., but also can be coated with local anti-infective ointment, such as erythromycin, etc., and in severe cases, need to be incised and drained. 2. Acute gastroenteritis: generally in the diet unclean, cold stimulation of diet, often manifested as abdominal pain, diarrhea, anal swelling, etc., you can take norfloxacin, ciprofloxacin and other anti-infective, can also be used in montelukast, Saccharomyces boulardii, etc. to stop diarrhea. 3. Pelvic inflammatory disease: such as chronic pelvic inflammatory disease, chronic appendicitis and other inflammatory diseases spread to the rectal cavity to stimulate the rectum, can also cause hepatic distension, available clindamycin, metronidazole, cephalosporin drug treatment. 4. Colorectal tumor: when the tumor invades and stimulates the rectum, anal distension will also occur, often accompanied by changes in bowel habits, blood in stool, diarrhea and constipation alternately, etc. At this time, surgery should be performed for radical treatment or chemotherapy, commonly used chemotherapeutic drugs include oxaliplatin, 5 fluorouracil, etc. When there is a feeling of anal distension, we should consult the hospital in time to clarify the cause of the disease, and use medication under the guidance of professional doctors to choose the appropriate treatment plan.