Palm long small transparent hard rice grain, may be epidermis thicker blisters, such as sweat herpes, can be used externally halometasone cream and other drugs; ringworm, can be used externally clotrimazole cream, terbinafine cream and other medications; palmoplantar warts, can be used externally through physical therapy medication. 1. Sweat herpes: the etiology is not clear, may be and environmental factors, genetic factors, infection factors, will cause the local rice size thick wall blisters, some will also appear itching and other symptoms. You can use halometasone cream, zinc oxide ointment and other drugs to treat it. 2. ringworm: fungal infection caused by blister ringworm, may also cause the palm of the hand long thick walled small blisters. You can use clotrimazole cream, terbinafine cream and other antifungal drugs to treat it. 3. palmoplantar warts: human papilloma virus infection caused by benign skin superfluous organisms, at first there will be small shiny pimples, may lead to the palm of the hand long small transparent hard rice grains, you can take freezing, laser, electrocautery and other physical treatment methods, but also can be used externally fluoro uracil cream, Zanjirushi cream and other drugs treatment. It is recommended to go to the hospital for examination first to clarify the cause of the disease, the drug needs to be used under the guidance of a professional doctor to avoid abusing the drug by yourself.