Glutamyl transpeptidase is also known as γ-GT, and γ-GT 280 U/L is not normal. Gamma-GT is widely present in the body, mainly in the hepatocyte plasma and intrahepatic bile duct epithelium, and normal serum is derived from the liver, with a normal value of 3 to 50 U/L. When the extrahepatic bile ducts and intrahepatic obstruction, resulting in γ-GT excretion is blocked, with bile back into the blood and lead to γ-GT abnormalities, in addition to the body, such as kidneys, testes, lungs, heart, brain, muscle also contains γ-GT, so when pyelonephritis, encephalitis B, lobar pneumonia, myocarditis, cholecystitis, schistosomiasis, can also cause γ-GT abnormalities. In addition alcoholism, barbiturates, phenytoin, and male medications may also cause gamma-GT changes. In case of glutamyl transpeptidase 280U/L, it is recommended to consult the doctor for relevant tests to clarify the diagnosis and then follow the doctor’s instructions for timely treatment.