The specific dosage of Irbesartan for the treatment of proteinuria varies from person to person, and when the drug is used to reduce proteinuria, it is recommended to maximize the blockade of the RAAS system so as to achieve the maximum therapeutic effect, so patients can continue to increase the dosage to the maximal tolerated dose if they can tolerate it without any related adverse effects such as hypotension, elevated blood creatinine, and so on, in accordance with the doctor’s instructions. Usually recommended initial dose and maintenance dose of 150mg per day, blood pressure can not tolerate the use of 75mg per day, the use of Irbesartan 150mg per day when the patient does not feel uncomfortable, you can continue to increase the dose to the maximum tolerated level, the specific dosage recommended by the doctor’s advice. Irbesartan has the effect of activating the angiotensin II receptor in the body, promoting the release of prostaglandins and bradykinin in endothelial cells, and the formation of nitric oxide, improving vascular permeability, thus achieving the effect of regulating blood pressure. The study suggests that treatment with high-dose Irbesartan can better control the blood pressure of patients with chronic nephritis, and the improvement of renal function is also better, which can effectively reduce proteinuria, and the patient’s adverse reactions are controllable and well-tolerated. In general, Irbesartan 150mg per day can better control 24-hour blood pressure than 75mg per day, and for those who can not effectively control blood pressure and proteinuria, Irbesartan dosage can be increased to 300mg per day or higher dosage or increase other anti-hypertensive drugs. Irbesartan dosage specifically need to be adjusted in conjunction with the condition and blood pressure, blood creatinine and other conditions, it is recommended that patients timely regular hospital consultation, follow the doctor’s instructions to take medication.