How long melanoma can live is related to the stage of the tumor, treatment and the patient’s individual systemic condition, etc. There is no exact answer and cannot be generalized. Usually, 98% of patients with stage I and II melanoma without metastasis can live more than 5 years if they are treated actively; about 64% of patients with local metastasis in stage III can live more than 5 years after treatment; 23% of patients with distant metastasis in stage IV can live more than 5 years after treatment. However, there are still some individual differences in how long they can live. In addition, how long melanoma can live is also related to the location of tumor growth. Melanoma occurring in the extremities has a relatively good prognosis and may live longer, followed by melanoma occurring in the trunk, while melanoma occurring in the head, neck and face has a relatively poor prognosis and may live for a shorter period of time if not actively treated. Melanoma is a disease with a high degree of malignancy. Usually, the earlier the disease is detected and the earlier active treatment is started, the better the prognosis is and the longer the life span will be. Therefore, after the discovery of melanoma, one should actively follow medical advice for comprehensive treatment such as surgery, radiation therapy, chemotherapy, targeted therapy, etc. Keeping a relaxed mood is conducive to prolonging the survival time and improving the quality of life.