Glycylproline dipeptide aminopeptidase (GPDA) is an enzyme distributed in body fluids such as liver, kidney, connective tissue, and serum, but its physiological function is unknown. Because GPDA specifically hydrolyzes and releases glycyl-proline from the N-terminus of the peptide chain in collagen molecules, GPDA may be associated with collagen peptide degradation.
Glycyl-proline dipeptide aminopeptidase is distributed in salivary glands, serum, liver and kidney, and connective tissues, and serum GPDA activity gradually increases with age.
Normal human serum GPDA concentration is 44~116 U/L. High GPDA can be seen in primary hepatocellular carcinoma, secondary hepatocellular carcinoma, drug-induced liver damage and primary biliary cirrhosis, etc.; lower GPDA can be seen in gastric cancer, rheumatoid arthritis, systemic lupus erythematosus, acute lymphoblastic leukemia, lymphosarcoma and Hodgkin’s disease, etc.
For more information about Glycyl Proline Dipeptide Aminopeptidase (GPDA), please consult your physician. Seek immediate medical attention if you are unwell.