Post-burn scar proliferation seriously affects the morphological and functional recovery of patients after healing, and is one of the challenges in clinical medicine. Factors such as imbalance of collagen metabolism, proliferation and contraction of fibroblasts, and altered ratio of proteoglycan components in the dermal matrix are the basis of post-burn proliferative scar formation. Currently, scholars are actively searching for artificial or natural antagonistic factors. For example; anti-TGF a factor interferon, etc. However, the results are not satisfactory or have not been used clinically. Compression therapy for hyperplastic scarring is a long-standing method. It is commonly used to thin and tenderize post-burn scars and is accepted by most patients because of its simplicity and low burden. However, the results vary with different methods of use. Clinical data General data: Of the 167 patients in this group, 107 were male and 60 were female. Age 1 year – 70 years, average 29 years. The burn area was 1%-50%, average 28%, all were deep II or III degree burns, which healed by themselves or after skin grafting surgery. The follow-up period was 6 months to 1.5 years. The patients were treated with an elastic sleeve only after wound healing, without any other topical medication. Group 1 (61 patients): the elastic sleeve was worn for 18-24 hours per day for more than 6 months: Group 2 (55 patients): the elastic sleeve was worn for the next 18 hours per day and/or for 3 months; Group 3 (51 patients): no treatment with the elastic sleeve. The presence or absence of painful and itchy symptoms, the softness and flatness of the scar, and the color were observed. The effect was considered significant if there were no painful and itchy symptoms, the scar became softer and thinner, and the color became white close to normal skin: the presence of painful and itchy symptoms. A markedly congested, red, hard scar that is higher than the skin is considered significantly hyperplastic: those with symptoms or appearance between the 2 are considered improved. Discussion 1. Indications for elastic sleeve treatment: If the trauma heals in 10 days – 14 days, the elastic sleeve can be applied prophylactically to patients with black scar. If repair takes 14 days – 21 days, prophylactic compression therapy should be performed in all patients. If the red color fades at 2 months – 3 months, it is concluded that the scar will increasingly improve and compression therapy is not needed. If at 2 months the scar is still highly vascularized, bright red and progressively hardening, this is an indication that a scar will form and compression therapy must be continued. If the repair exceeds 21 days, pressure therapy must be applied for a long time. 2. The key to the success of compression therapy is “early”, “tight” and “long”. After the wound surface is healed, the pressure should be started as early as possible, after the scar is obvious, the pressure is not effective. The pressure should be 2.13kPa-2.39kPa. If the elastic sleeve becomes loose, it will lose its compression effect and must be replaced in time. If the patient feels that it is too tight and difficult to tolerate, it can be relaxed slightly to reduce the pressure, but the elastic sleeve cannot be released. The compression sleeve must be worn for 18-24 hours a day for at least 4-6 months, or even up to 2 years. Premature relaxation may allow the scar to rebound. Generally, after 4-6 months of continuous compression, the congestion of the scar disappears and the bulge becomes flat. After 8-10 months, the compression can be terminated in the majority of cases, and the criteria for termination of compression is that the scar becomes softer and whiter in color. 3. The mechanism of pathological-histological changes of compression therapy is not clear. It may be that pressure causes local ischemia, activates tissue metabolism and increases collagenase activity. Due to local hypoxia and ischemia, the number of ducts is reduced, the blood supply to the scar tissue is decreased, and the partial pressure of oxygen in the cells is reduced in the hypoxic state. The function of mitochondria decreases or even stops. Morphological changes occur at the same time. For example, mitochondria swell and vacuolar degeneration. In this way, mitochondria, which bear the main use of cellular biological oxidation, cannot release energy well in a series of oxidative phosphorylation processes, resulting in the inhibition of fibroblast proliferation and finally degenerative necrosis, and the function of generating collagen fibers and matrix is greatly reduced, which leads to thinning and softening of the scar. 4. The effect of compression therapy is better if combined with other drugs that inhibit scar proliferation, such as silicone spray film, Conrad, etc.