The most common use of progesterone injection is intramuscular injection, the progesterone injection solution directly into the syringe, in the patient’s gluteus maximus muscle for intramuscular injection, can both sides of the buttocks in turn. Because progesterone injection is an oily solution, the concentration of the drug is relatively large, so there will be resistance in the middle of the injection process, so patients will feel pain and swelling at the injection site, which is a normal situation. And the site of myoinjection is prone to hard knots or pain, and it takes a few days to recover. When injecting progesterone, do not go too fast, as this may cause pain to the patient, but push the drug in slowly and evenly. Do not repeatedly inject in one area, which tends to increase the probability of local hard knots. When the condition is stable, the injection can be changed to oral, oral progesterone are progesterone soft capsules, and also dydrogesterone tablets.