In the diagnosis of malarial nephropathy, urine examination reveals a saucy red or soy sauce colored urine, and in some patients who have been untreated for a long time, nephrotic syndrome may develop. Plasmodium infection is the only cause of this disease. So how to diagnose urine saucy red or soy sauce colored? The following is a brief explanation. The main clinical manifestations of malarial nephropathy are hypertension, proteinuria, hematuria and edema. Patients with acute renal failure due to malaria may have high fever, profuse sweating, and insufficient water intake resulting in reduced effective blood volume, followed by increased compensatory sympathetic activity, increased catecholamine secretion, and strong renal vasoconstriction, resulting in significantly reduced renal blood flow, which may then cause or aggravate renal insufficiency. The main clinical manifestation of chronic progressive renal damage due to malaria is nephrotic syndrome. Most patients die within 1 year, with a high mortality rate (about 13%). The nephrotic syndrome is usually complicated by P. terrestris, mostly in children. Typical nephrogenic edema, even pleural effusion and ascites, with hepatomegaly, splenomegaly and anemia, appears within 3 weeks after the control of P. terrestris. After the edema subsides, proteinuria and renal impairment and hypertension may persist. In a few cases, it is acute renal failure. It is recommended that if patients develop the above symptoms, they should actively go to the hospital for consultation to achieve early detection, early diagnosis and early treatment to avoid delaying the disease.