Degeneration of the knee cartilage is usually not curable, as degenerative changes in the knee cartilage are a normal phenomenon. The main treatments include medications such as the non-steroidal anti-inflammatory drugs celecoxib capsules and loxoprofen sodium tablets, and the cartilage-nourishing drug chondroitin sulfate. In addition, patients should also adhere to rehabilitation exercises to enhance the strength and power of the muscles around the knee joint to protect the knee joint and inhibit excessive development of the lesion. The patient’s weight should also be strictly controlled to reduce weight bearing on the knee joint, which is also beneficial in slowing down the degeneration of the knee joint. In summary, knee cartilage degeneration cannot be completely cured, but can only be moderately slowed down and the resulting clinical symptoms improved.