If the tumor of gastric sinus cancer appears to be adherent to pancreas, firstly consider that gastric sinus cancer invades into pancreas, and then surgical resection can be considered; if surgical treatment is not feasible, only radiotherapy or internal medicine conservative treatment can be considered. 1. Surgical resection: if there is a possibility of surgery after comprehensive clinical examination and evaluation, surgical resection can be chosen. 2. If there is no indication for surgical treatment due to middle and advanced gastric sinus cancer with pancreatic infiltration, palliative treatment is generally recommended to control cancer progression and prolong survival. For example, chemotherapy, radiotherapy and biotargeting and other treatment modalities can be used for comprehensive treatment to control the tumor, prolong the survival time and improve the quality of life as far as possible. 3 Acid-suppressing drugs such as omeprazole and pantoprazole can also be taken as prescribed by doctors to help relieve stomach pain, acid reflux, nausea, vomiting and other discomforts, and analgesic drugs such as oxycodone hydrochloride and morphine can also be applied appropriately if the pain is severe to alleviate the pain of patients. Gastric sinus cancer patients should actively follow the doctor’s prescription for treatment, and keep a good mindset, pay attention to rest, avoid overwork, and regular follow-up, etc., so as to benefit their own condition and improve the quality of life as much as possible.