The resistance time of Abiraterone is usually about 15 months, but some patients can be up to several years, and it has a lot to do with their own physique, and the exact time of resistance varies from person to person. After the emergence of drug resistance of abiraterone, you can not continue to take, you can choose other drugs instead of treatment, such as olaparib. Abiraterone is the main drug for treating metastatic prostate cancer, but drug resistance is its biggest drawback, which is also a problem with the majority of targeted drugs. Abiraterone resistance time is affected by a variety of factors, such as personal constitution, method of use and so on, so there is a certain variation in the time of resistance, from the point of view of some of the existing data, the general population resistance time is about 15 months. Resistance to abiraterone, and then continue to take no therapeutic effect, then you need to stop the drug in time, it is recommended to do genetic testing, such as the existence of BRACA mutation, can be applied to olaparib. Because of the obvious individual differences in drug treatment, the specific situation must be under the guidance of the doctor to use the drug.