Menstruation without follicles is classified as anovulatory menstruation. There are many reasons for anovulatory menstruation, most commonly in adolescent or menopausal women. In adolescent girls, due to the imperfect development of the regulation of the hypothalamic-pituitary-ovarian axis and the irregular secretion of gonadotropins and sex hormones, the follicles cannot be stimulated to develop and mature, and ovulation occurs. With age, the hypothalamus and ovary functions are further developed and follicle development occurs. In menopausal women, there is no follicular development because of the decline of ovarian function and the depletion of follicles. The above phenomenon is physiologic and does not require treatment if menstruation is normal. Pathological causes are common in women of childbearing age, such as premature ovarian failure, pituitary tumors and so on, affecting follicular development, resulting in the absence of follicles. This will affect pregnancy, and hormonal sequential therapy or short-acting contraceptive pills should be taken to regulate the functions of the pituitary gland and ovaries, and ovulation stimulation drugs should be used after menstruation is normal.