Gliomas grow infiltratively, like the distribution of tree roots in the soil, the further away from the trunk, the more sparse the roots become. All current imaging methods that show tumor boundaries (CT, MRI, ultrasound, fluorescence, etc.) underestimate the extent of glioma infiltration. Currently, glioma surgery essentially defines the extent of resection based on imaging boundaries, and imaging-based surgery is actually far less extensive. The determination of the cytological boundaries of glioma tumors is a hot issue that scientists have explored from multiple dimensions, and so far, there is currently no good method to determine the extent of glioma invasion. Theoretically, it can be assumed that glioma has no boundary. The absence of a border also prevents the definition of total resection, and therefore the glioma surgical guidelines recommend maximum safe resection rather than total resection. Instead of getting too hung up on glioma boundaries, we would have to keep resecting until the boundaries of the adjacent cortex and subcortical functional structures are reached. For glioma surgery, due to the borderless nature of gliomas, we need to shift our philosophy of working around the cytological boundaries of gliomas and instead focus on pinpointing the functional boundaries around the tumor. We need to weaken the tumor boundaries and strengthen the concept of functional boundaries, with surgery cutting all the way to the nearby functional boundaries to truly achieve maximal safety resection.