Hyperbilirubinemia can occur for a variety of reasons. Treatment is mainly carried out by clarifying the cause of the occurrence of increased bilirubin and then treating the disease causing the bilirubin elevation. 1.For the elevated bilirubin caused by hemolytic anemia, it is mainly due to the rapid destruction of red blood cells and the breakdown of hemoglobin components into bilirubin, which exceeds the processing capacity of the liver and causes elevated bilirubin. Therefore, the treatment focuses on treating hemolytic anemia. The causes of this disease include drugs, blood transfusion, blood system disorders, side effects of drugs, and its treatment should be tailored to the specific situation. 2. Other diseases, such as viral hepatitis, cirrhosis and alcoholic and fatty liver disease, have insufficient capacity to process bilirubin due to liver damage. These diseases are mainly preventive in nature, and the liver function is usually actively reviewed. For viral hepatitis with abnormal liver function, active antiviral and liver protection treatment is required. Alcoholic liver disease requires abstinence from alcohol, and fatty liver disease requires diet control and standardized lipid-lowering drug treatment. 3, there are also some bilirubin elevation caused by cholelithiasis, pancreatitis or biliary tumor, it is important to lift the biliary obstruction due to various reasons, so as to facilitate the smooth discharge of bile into the intestine, which can reduce the bilirubin elevation caused by these diseases. 4, in addition, some drugs may induce hyperbilirubinemia by damaging liver function, including certain antibiotics, anticonvulsants, antifungal drugs, contraceptives, statins and some cold medicines. Some herbal preparations also have an effect on liver function. Therefore, you need to pay attention to the safety of medication in general, and make sure to use it safely under the guidance of your doctor. The treatment of hyperbilirubinemia depends on the underlying cause, and the problem should not be viewed in isolation; the cause of the elevated bilirubin needs to be actively sought out and effective treatment given instead.