Hepatitis B immunoglobulin and hepatitis B vaccine are the most effective drugs to prevent hepatitis B virus infection, but there is a big difference between the two, as follows: 1, hepatitis B immunoglobulin: can directly neutralize the hepatitis B virus, generally used in newborns to block mother and child, and medical personnel or other people unintentionally exposed to the hepatitis B virus need emergency prevention, only need to inject hepatitis B immunoglobulin; 2, hepatitis B vaccine The hepatitis B vaccine is a genetic vaccine that stimulates the body to produce its own antibodies against the hepatitis B virus by injecting the vaccine, that is, to produce its own immunoglobulin against hepatitis B. It is widely used in newborns and is the best protection for doctors and people who have been in contact with hepatitis B patients for a long time.