A high level of glycan antigen 125 (CA125) and fluid accumulation in the abdominal cavity may be a sign of ovarian tumors, cirrhosis and other diseases. CA125 is a tumor marker, and its increased level is commonly found in ovarian tumors, but also in malignant tumors such as breast cancer, pancreatic cancer, gastric cancer, lung cancer, colorectal cancer, and so on; in addition, elevated CA125 can also be found in benign diseases, such as endometriosis, pelvic inflammatory disease, ovarian cysts, pancreatitis, hepatitis, cirrhosis, and so on. Elevated CA125 and fluid in the abdominal cavity may be associated with cirrhosis, hepatocellular carcinoma, ovarian tumors and other diseases. It is necessary to consult a doctor in time, complete laboratory, imaging, pathology and other related examinations to clarify the cause of the disease and standardize the diagnosis and treatment.