Bone puncture is a procedure that does not affect the new crown vaccination, but it is necessary to clarify whether the patient has other diseases that are contraindications to the new crown vaccination, and it is best to confirm with the attending physician before making a decision. Bone marrow aspiration refers to bone marrow aspiration, which is a commonly used technique to take bone marrow fluid, and is applicable to the examination of various blood diseases, and is also commonly used for cytological, bacteriological and parasitic examinations. Bone marrow aspiration is generally less invasive and is a safe and effective test. However, if it is not performed properly, there is a risk of bleeding or infection, and anti-infection treatment is required. New Crown vaccination is not allowed when fever or infection occurs. The current contraindications for new crown vaccination are allergy, fever, epilepsy, pregnancy, and acute stages of various chronic diseases. Bone puncture this operation does not affect the new crown vaccination, but for the bone marrow puncture after the patient can be vaccinated, need to be based on their own postoperative recovery and the presence of other diseases, or whether in the acute morbidity, should be carried out under the judgment of the attending physician, do not decide on their own, so as not to cause adverse reactions.