Patients with blepharitis, also known as blepharitis, who experience significant discomfort with itchy eyes after applying erythromycin ophthalmic ointment, may wash the medication and seek prompt medical attention. Patients with blepharitis who develop very itchy eyes after applying erythromycin ophthalmic ointment need to stop using erythromycin ophthalmic ointment immediately and wash the medication thoroughly with water. Considering the allergic reaction caused by erythromycin ophthalmic ointment, patients may experience discomfort such as eye itching, stinging, edema, and congestion. If necessary, patients can follow the doctor’s instructions to use cetirizine, loratadine and other anti-allergy drugs treatment. At the same time, patients need to avoid rubbing their eyes with their hands, avoiding the use of expired eye ointment and so on, in order to prevent the aggravation of the condition. Patients with blepharitis are advised to seek prompt medical attention to evaluate their condition and follow their doctor’s instructions.