Ankle joint effusion requires the use of drugs according to its causes, such as trauma, bacterial infection, gouty arthritis, osteoarthritis, etc. Antibiotics, non-steroidal anti-inflammatory analgesic and uric acid-lowering drugs are chosen after clear diagnosis. 1. Trauma: Trauma can cause aseptic inflammation of the ankle joint, resulting in ankle joint effusion. For treatment, hot compresses can be applied to it, and safflower oil can be applied locally to improve the symptoms. Usually, it will be gradually relieved after sufficient rest and no special treatment is needed. 2. Bacterial infection: Bacterial infection in the ankle joint can cause septic effusion, and the treatment can follow the doctor’s instructions to take antibiotics, such as amoxicillin, cefixime and so on. 3. Gouty arthritis: gouty arthritis can also cause ankle joint effusion, the treatment is based on lowering uric acid, can be prescribed to take uric acid-lowering drugs, such as febuxostat, colchicine. 4. Osteoarthritis: Osteoarthritis occurs in middle-aged and old people, and can also cause ankle joint effusion. Treatment is mainly based on hot compresses, massage, rest, if there is obvious pain, you can take non-steroidal anti-inflammatory analgesic drugs, such as ibuprofen, acetaminophen. In addition to the above factors, rheumatoid arthritis, rheumatoid arthritis, tuberculous joint effusion, etc., can lead to cause ankle joint effusion. Therefore, after the appearance of symptoms, patients are advised to go to the hospital in a timely manner, follow the doctor’s instructions to use medication, and not to use it indiscriminately, so as not to lead to adverse consequences.