A good combination of antihypertensive drugs can reduce the adverse effects of drugs and help improve the efficacy. In actual clinical work, patients can use combination therapy as long as they achieve grade 2 or higher hypertension, which is more conducive to achieving the target blood pressure. Commonly used combination drug regimens are as follows: First, ACEI or ARB combined with calcium antagonists, the advantage of the combination regimen is both antihypertensive and cardiovascular protective effects. Second, ACEI or ARB combined with thiazide diuretics, combined features are helpful to improve the long-term prognosis of heart failure and prevent electrolyte disorders. Third, the combination of dihydropyridine calcium channel blockers and beta-blockers, this combination can lower blood pressure and help improve the blood supply to the heart, effectively alleviate angina pectoris, patients should choose the appropriate antihypertensive treatment plan according to their specific disease, to achieve the ideal antihypertensive effect.