Total prostate-specific antigen, abbreviated as t-PSA, should have a normal value of <4 μg/L. Elevated levels are most commonly seen in prostate cancer, but can also be seen in some benign diseases. In addition, various operations that stimulate the prostate can also cause mild elevation. Elevated t-PAS level can be seen in 60-90% of prostate cancer patients, and the higher the level, the more supportive the diagnosis of prostate cancer. In addition, t-PSA tends to decrease after prostate cancer surgery, and if the level rises again after surgery, it suggests that the tumor has metastasized or recurred; Some benign diseases, such as prostatitis and benign prostatic hyperplasia, can also cause mild elevation of t-PSA, but most of them are in the range of 4-10 μg/L. In this range, it is necessary to identify the disease. Differential diagnosis is required within this range. In addition, stimulation of prostate tissue by rectal palpation, prostate massage, catheter placement, and other operations can also cause mild elevation of t-PSA, which should be reviewed again after a period of time to rule out the possibility of abnormality. It is recommended to go to the hospital in time to consult a professional doctor to determine the elevated level of t-PSA, and if necessary, a prostate MRI or puncture biopsy can be performed to make a clear diagnosis.