Tacrolimus ointment costs around $100 to $130 and tacrolimus capsules cost around $300 to $1500. The price of tacrolimus can vary due to the different manufacturers, brands, and specifications of tacrolimus. Tacrolimus is a powerful immunosuppressant, mainly used to prevent rejection reaction after solid organ or bone marrow transplantation, but also used for patients with autoimmune diseases, such as systemic lupus erythematosus, autoimmune eye disease, atopic dermatitis and so on. Burning sensation of the skin, itching, rosacea, etc. may occur during the use of topical tacrolimus; oral use of the drug may be diarrhea, vomiting, peripheral edema, skin rash, as well as erythema, anemia, headache, insomnia, and other adverse reactions, and in severe cases, cardiac arrest, myocardial infarction, gastrointestinal tract perforation, atrial fibrillation, epilepsy, and so on. It is contraindicated for those who are allergic to tacrolimus, or other macrolides and any of the components of this product. It is recommended to use it under the supervision of a doctor, and inform the doctor in case of any of the above adverse reactions.