Liver failure is generally not curable, but the disease process can be slowed and symptoms improved. The main methods include general supportive treatment, anti-inflammatory liver preservation and etiologic treatment. 1. General supportive treatment: supportive treatment should be carried out according to the specific clinical manifestations of liver failure. Early diagnosis and treatment should be made when corresponding symptoms appear, and corresponding comprehensive treatment measures should be taken for different symptoms, such as providing patients with required nutrition, supplementing fluids and electrolytes appropriately, maintaining water and electrolyte balance, and actively preventing and treating complications. 2. Anti-inflammatory and hepatoprotective drugs: anti-inflammatory and hepatoprotective drugs, mainly glycyrrhizic acid anti-inflammatory and hepatoprotective drugs, such as diammonium glycyrrhizinate, compound glycyrrhizinate tablets, etc., and also such as reduced glutathione, polyenylphosphatidylcholine and so on. 3. Etiologic treatment: Hepatitis B-induced liver failure should be continued with antiviral treatment, such as entecavir, etc. If it is drug-induced liver failure, it should be continued with antiviral treatment. If the liver failure is caused by drugs, the corresponding drugs should be stopped. If the liver failure is caused by long-term or large amount of alcohol consumption, the alcohol should be stopped in time. 4. If the above medication fails to relieve the disease, artificial liver support therapy and liver transplantation can be used. Individualized treatment should be carried out for different patients, and it needs to be judged according to the degree of the disease and the progress of the patient’s condition.